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Test di clonalità linfoide: alcune domande e risposte per capire di cosa si tratta, come usarlo e come interpretarlo

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32.


The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.

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Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem Ipsum.Contrary to popular belief, Lorem Ipsum is not simply random text. It has roots in a piece of classical Latin literature from 45 BC, making it over 2000 years old. Richard McClintock, a Latin professor at Hampden-Sydney College in Virginia, looked up one of the more obscure Latin words, consectetur, from a Lorem Ipsum passage, and going through the cites of the word in classical literature, discovered the undoubtable source. Lorem Ipsum comes from sections 1.10.32 and 1.10.33 of "de Finibus Bonorum et Malorum" (The Extremes of Good and Evil) by Cicero, written in 45 BC. This book is a treatise on the theory of ethics, very popular during the Renaissance. The first line of Lorem Ipsum, "Lorem ipsum dolor sit amet..", comes from a line in section 1.10.32.


The standard chunk of Lorem Ipsum used since the 1500s is reproduced below for those interested. Sections 1.10.32 and 1.10.33 from "de Finibus Bonorum et Malorum" by Cicero are also reproduced in their exact original form, accompanied by English versions from the 1914 translation by H. Rackham.

I believe that a simple and unassuming manner of life is best for everyone, best both for the body and the mind.

Albert Einstein

Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only five centuries, but also the leap into electronic typesetting, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages, and more recently with desktop publishing software like Aldus PageMaker including versions of Lorem.

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  • Cara Piera,
    secondo letteratura possiamo avere con la PARR sia falsi positivi sia falsi negativi che ti elenco qua sotto:
    FALSI NEGATIVI:
    1. Numero di cellule neoplastiche inferiore alla quantità minima rilevabile
    2. Riarrangiamenti non riconosciuti dai primers utilizzati
    3. Delezioni nel cromosoma corrispondente (raro)
    4. Origine Natural Killer
    5. Presenza di pro-genitori senza riarrangiamento

    FALSI POSITIVI:
    1. Riaggangiamento clonale in casi di infezioni da E. canis, B. burgdorferi, Bartonella spp. e R. rickettsii
    2. Descritto in ridotto numero di casi di Leucemia Mieloide Acuta
    3. Istiocitoma

    In aggiunta, considera che sensibilità e specificità possono variare in base al tipo di materiale che viene utilizzato (fresco,fissato, citologico e versamento). Da letteratura viene riportato come la specificità PARR nel cane si attesti intorno al 94% e nel gatto intorno 90%. Per quanto riguarda la sensibilità nel cane è intorno ai 70-85% e nel gatto attorno al 65%. Questo dato può' variare tra laboratorio. Per ultimo i dati che ti ho riportato sono per lo più associati a studi su linfomi nodali. Per quanto riguarda le altre sedi sappiamo poco.

  • Sono due cose diverse, nell'articolo è spiegato: l'immuno-fenotipizzazionione ti serve per sapere se la popolazione neoplastica presente è B o T, ma tu già devi avere già una diagnosi di neoplasia. La PARR serve per cercare di capire se sei davvero di fronte ad una neoplasia o ad una flogosi. E' l'obiettivo finale che è differente.
    walter

  • Ospite - Piera

    Quali sono i casi in cui con una PARR posso avere un falso negativo?

  • Ospite - flavia invernizzi

    Ma quali sono le indicazioni per preferire PARR ad immunofenotippizazzione? Grazie. Flavia I.

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